2020年1月，日本东京大学的研究团队在期刊《Gerontology》上发表文章，探究α-甘油磷酸胆碱(α-GPC)如何防止衰老及其相关的认知功能下降。研究发现，α-GPC的摄入减少了与长期增强相关的基因表达水平随年龄增长的下降。

 

 

 

该研究团队以小鼠为模式生物，将其分为3组。饲喂固体饲料的老年小鼠对照组（105-118周龄）、幼龄小鼠对照组（7周龄）和用含GPC的食物喂养的老年组小鼠，用来研究海马区的基因表达水平，检测α-GPC摄入对多种mRNA表达水平的影响。结果发现，α-GPC喂养的老年小鼠长期增强相关基因的mRNA表达水平显著高于老年对照组，表明α-GPC摄入对与衰老相关的长期增强相关基因mRNA表达水平下降具有抑制作用。

 

 

 

α-GPC的摄入，改善了与长时程增强和β氧化相关的基因表达水平随年龄增长而下降的情况，这一研究成果为阐明α-GPC延缓衰老的分子机制奠定了基础。

【关键词】α-甘油磷酸胆碱、抗衰老作用、基因表达、认知功能、味觉敏感性、β-氧化

【原文标题】Efficacy of Long-Term Feeding of α-Glycerophosphocholine for AgingRelated Phenomena in Old Mice

【标题翻译】长期饲喂α -甘油磷胆碱对老龄小鼠衰老相关现象的影响

【文献作者】 Nasataka Narukawa、Aya Kamiyoshihara、Hanae lzu、Tsutomu Fujii、

Kiminori Matsubara、Takumi Misaka

【发布杂志】Gerontology

【发布时间】2020年1月

【影响因子】3.441

【原文链接】https://doi.org/10.1159/000504962

【文献节选】

α-Glycerophosphocholine (GPC) is a natural source of choline. It reportedly prevents aging-related decline in cognitive function, but the underlying mechanism remains unclear. Although it is understood that aging influences taste sensitivity and energy regulation, whether GPC exerts antiaging effects on such phenomena requires further elucidation. Here, we used old C57BL/6J mice that were fed a GPC-containing diet, to investigate the molecular mechanisms underlying the prevention of a decline in cognitive function associated with aging and examine the beneficial effects of GPC intake on aging-related phenomena, such as taste sensitivity and energy regulation. We confirmed that GPC intake reduces the aging-related decline in the expression levels of genes related to long-term potentiation. Although we did not observe an improvement in aging-related decline in taste sensitivity, there was a notable improvement in the expression levels of β-oxidation-associated genes in old mice. Our results suggest that the prevention of aging-related decline in cognitive function by GPC intake may be associated with the improvement of gene expression levels of longterm potentiation. Furthermore, GPC intake may positively influence lipid metabolism.